Brain structure linked to symptoms of restless legs syndrome

Press Release:

MINNEAPOLIS – People with restless legs syndrome may have changes in a portion of the brain that processes sensory information, according to a study published in the April 25, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Restless legs syndrome is a disorder that causes uncomfortable sensations in the legs, accompanied by an irresistible urge to move them. It often occurs in the evening and at night, sometimes affecting a person’s ability to sleep. In some cases, exercise may reduce symptoms. Iron supplements may also be prescribed if there is an iron deficiency. For more serious cases, there are also medications, but many have serious side effects if taken too long.

“Our study, which we believe is the first to show changes in the sensory system with restless legs syndrome, found evidence of structural changes in the brain’s somatosensory cortex, the area where sensations are processed,” said study author Byeong-Yeul Lee, PhD, of the University of Minnesota in Minneapolis. “It is likely that symptoms may be related to the pathological changes in this area of the brain.”

The brain’s somatosensory cortex is part of the body’s somatosensory system, which is made up of nerves and pathways that react to changes either inside or outside the body. This system helps a person perceive touch, temperature, pain, movement and position.

The study involved 28 people with severe restless legs symptoms who had the disorder for an average of 13 years. They were compared to 51 people of the same age without the disorder. Each participant had a brain scan with magnetic resonance imaging (MRI).

Researchers found that people with restless legs syndrome had a 7.5 percent decrease in the average thickness of brain tissue in the area of the brain that processes sensations compared to the healthy participants. They also found a substantial decrease in the area of the brain where nerve fibers connect one side of the brain to the other.

Lee said, “These structural changes make it even more convincing that RLS symptoms are stemming from unique changes in the brain and provide a new area of focus to understand the syndrome and possibly develop new therapies.”

He said while the study shows a possible link between symptoms and the areas of the brain that process sensory information, it is possible that symptoms may instead be linked to impaired function in other parts of the sensory system.

Advertisement:

SaleBestseller No. 1
Hyland's Restful Legs PM, Nighttime Formula, Calms Agitated Legs so You Can Sleep, 50 Quick Dissolving Tablets
  • RELIEF OF AGITATED LEGS: Natural relief for the uncontrollable urge to jerk or move legs with accompanying occasional sleeplessness and disrupted sleep.
  • EASY TO USE: Quick-dissolving tablets that melt in your mouth instantly to relieve itching, crawling, tingling legs and leg jerk with occasional sleeplessness and disrupted sleep.
  • 50 TABLETS = UP TO 25 DOSES of Hyland's Restful Legs PM quick-dissolving tablets
  • Dissolve 2-3 tablets under your tongue for fast & effective relief of agitated legs so you can sleep.
  • Gentle botanical sleep formulation helps you fall asleep and stay asleep with no morning grogginess.
SaleBestseller No. 2
MagniLife Relaxing Leg Cream, Deep Penetrating Topical for Pain and Restless Leg Syndrome Relief, Naturally Soothe Cramping, Discomfort, and Tossing with Lavender and Magnesium - 4oz
  • NATURAL RELIEF - MagniLife penetrating leg cream helps to relax and soothe the uncomfortable sensations that can make it difficult to fall asleep. Relaxing Leg Cream is a go-to when your legs just won’t stay still. Helps to calm the discomfort and restlessness so that you can get the sleep you need and wake up feeling refreshed and ready for whatever the day brings.
  • ALL-NATURAL INGREDIENTS - Naturally derived, intense moisturizing herbal cream soothes aching, busy legs with magnesium, aloe, cudweed, lavender, sage and ylang-ylang. Our deep penetrating, non-greasy formula contains active ingredients to help deliver fast-acting, serious relief when you need it most.
  • HOW TO USE - Provides a natural alternative to other sleep aids. For best results, apply generously into legs and feet before bedtime. If you are tired of tossing and turning, now you can get the rest you need without side effects or the risk of dependency. Reapply if necessary. Results may vary.
  • SAFE, PLANT-DERIVED TOPICAL - A great benefit of our cream is it does not interfere with other medications. A safe option for someone who is currently taking medication or wants to avoid medicines that can be harsh on the body.
  • TRUSTED BRAND WITH YOU IN MIND - MagniLife has been a trusted business for over 20 years. All of our products are developed and manufactured in our state-of-the art facilities. Made with highly qualified formulators to ensure excellence in quality and consistency, we ensure top quality products and are dedicated to providing products that help to improve quality of life. Start your journey to a healthy lifestyle today!
SaleBestseller No. 3
Calm Legs Natural for Natural Itching, Crawling, Tingling and Agitated Leg with Iron, Magnesium, and Valerian Root (60 Tablets)…
  • CALM LEGS. SUPPORT LEG MUSCLE RELAXATION: Natural support of the compelling urge to jerk or move legs. Calm Legs supports night time leg rest and with sensations of itching, tingling, crawling and the urge to move legs.
  • SAFE AND ABSORBABLE. Iron, magnesium, valerian root, B12, folic acid & other natural ingredients, offer an absorbable, safe, and effective formula to support better sleep. It helps support a healthy circulation.
  • SLEEP GREAT AGAIN. Calm Legs helps with the creepy, crawling feeling starting with more peaceful sleep. Boost daytime energy levels, sharpen mental alertness, and improve your mood as you use Calm Legs
  • RAPID RELIEF: CalmLegs supports leg muscle relaxation from that creepy-crawly feeling, starting with more peaceful sleep. Deep, restful slumber boosts daytime energy levels and sharpens mental alertness.
  • SAVE WITH SUBSCRIBE AND SAVE. New Subscribe and Save program with Amazon making sure you never run out of Calm Legs
SaleBestseller No. 4
Hyland's Restful Legs Tablets 50 ea (Pack Of 4)
  • RELIEF OF AGITATED LEGS: Natural relief of the compelling urge to jerk or move legs to relieve sensations of itching, tingling, crawling and the urge to move legs
  • EASY TO USE: Quick-dissolving tablets that melt in your mouth instantly to relieve itching, crawling, tingling legs and leg jerk
  • 50 TABLETS = UP TO 25 DOSES of Hyland's Restful Legs quick-dissolving tablets
  • SAFE AND NON-HABIT FORMING: Our gentle homeopathic formulas are made with all natural active ingredients. There are no known side-effects and will not conflict with any medications you may be taking
  • HIGHEST STANDARD OF QUALITY: All of Hyland's products follow the manufacturing and quality practices outlined in the Homeopathic Pharmacopoeia of the United States (HPUS) and are regulated by the Food and Drug Administration
Bestseller No. 5
Navigating Life with Restless Legs Syndrome (Brain and Life Books)
  • Spector (Author)
  • English (Publication Language)
  • 272 Pages - 09/03/2024 (Publication Date) - Oxford University Press (Publisher)
Bestseller No. 6
Hyland's Restful Legs PM, Nighttime Formula, Calms Agitated Legs so You Can Sleep, 50 Quick Dissolving Tablets (Pack of 2)
  • RELIEF OF AGITATED LEGS: Natural relief for the uncontrollable urge to jerk or move legs with accompanying occasional sleeplessness and disrupted sleep.
  • EASY TO USE: Quick-dissolving tablets that melt in your mouth instantly to relieve itching, crawling, tingling legs and leg jerk with occasional sleeplessness and disrupted sleep.
  • 100 TABLETS = UP TO 50 DOSES of Hyland's Restful Legs PM quick-dissolving tablets
  • Dissolve 2-3 tablets under your tongue for fast & effective relief of agitated legs so you can sleep.
  • Gentle botanical sleep formulation helps you fall asleep and stay asleep with no morning grogginess.
Bestseller No. 7
Approved Science Restlex - 420 mg Magnesium Glycinate Blend, L-theanine 200 mg - 60 Capsules
  • Rest Response - Calming herbs foster better sleep and relaxation.
  • Circulation Station - Contains essential B Vitamins and Vitamin E.
  • Muscle Maintenance - Muscles need Iron and Magnesium for optimal function.
  • Attention To Detail - Contains BioPerine for added bioavailability.
  • Commitment To Integrity - Made in the USA in a GMP-certified facility with third-party testing.
SaleBestseller No. 8
Ultra Research Restless Legs for Restless Legs Relief, 15 in 1 Formula, 90 Tablets, 45 Days Supply
  • Muscle Support: Magnesium and iron are super important for your nerves and muscles both of which are supporting your legs health.
  • Calming Herbal Relief: Our proprietary blend including Valerian and Lavender provides natural effects to calm legs.
  • Support Restfulness: Ingredients like Lavender promote a more restfulness, helping and supporting Restless Legs.
SaleBestseller No. 9
Miracle Plus Magnesium Cream For Leg Relief | Magnesium Lotion Calming Leg Cream Herbal Moisturizer Topical Body Butter Soothes + Calms Sensations, Itching, & Shaking, 8 Oz
  • ✅ MAGNESIUM CREAM – Magnesium deficiency in modern society has increasingly become more common & can worsen leg sensations during the evening. The use of a topical Magnesium Lotion allows for direct absorption into the deeper layers of skin, targeting problem areas, providing relief, & promoting cellular health. Magnesium Leg Cream also provides soothing effects, deficiency correction, symptom management, muscle relaxation, improved skin texture, & moisturizing skin nourishment.
  • ✅ NATURAL RELIEF – A great benefit of our Magnesium Leg Relief Lotion is that it does not interfere with other medications and is a safe option for those wanting to avoid taking potentially harsh medicines on the body. Our deep penetrating, non-greasy herbal formula contains active ingredients like Magnesium, L-Arginine, Vitamin E & B12, Chamomile, Ylang Ylang, Sage Extract, & Aloe Vera that soothe aching, busy legs to help deliver fast-acting, serious relief when you need it most.
  • ✅ RELAXING LEG CREAM – Dermatologist-Tested, Allergy-Tested, & Clinically-Tested Formula. After a long day or a workout, nothing feels better than our soothing lavender scented Magnesium Lotion. Massage it onto desired areas to help relax & refresh overused muscles + joints. Penetrating Magnesium Leg Lotion helps to relax & soothe the uncomfortable sensations that can keep you up at night. Relaxing Leg Cream is a go-to when your legs just won’t stay still.
  • ✅ NON-GREASY, EASILY ABSORBS – Intense moisturizing herbal leg & body cream brightens + nourishes dry skin, while also soothing annoying sensations with Magnesium, Vitamin C, Chamomile, Aloe Vera, Vitamin B, Phytic Acid, Lavender, Ylang Ylang, Sage Herbs, & more. This topical Magnesium Lotion bypasses the digestive system, allowing for faster absorption into the body compared to oral magnesium supplements, calming problem areas & leaving your skin feeling soft & supple.
  • ✅ COMMIT TO CONSISTENCY – For maximum effectiveness, incorporate this Magnesium Calming Cream into your nightly skin care routine and continue daily use for at least 3 - 4 weeks to support maximum absorption, to enhance your skin’s natural overnight regeneration process, & to allow your skin to fully absorb the minerals. Manufactured in our FDA-Regulated & Inspected state-of-the-art Laboratory in Chicago, USA. Free from any harsh chemicals, mineral oil, parabens, & drying alcohols.
SaleBestseller No. 10
SHINE WELL Calf Massager for Circulation, Leg Compression Massager for Circulation with 3 Modes 3 Intensities 2 Timing, for Restless Legs Syndrome Relief, FSA HSA Eligible
  • Leg Massager for Circulation: Shine Well leg massager machine has 2+2 airbags inside, provide air kneading massage for your calf foot and arms, The air pressure leg massager for relaxation have multiple massage techniques helps pain relief and restless legs syndrome relief, improve circulation, provides a comfortable massage experience for you.
  • 3 Massage Modes & 3 Intensities: The electric calf massager for circulation has Sequence, Circulation and Whole massage 3 modes and 3 Intensities give you or your family personalized massage experience from weak to strong, meet various usage scenarios and needs. Young massagere or the elderly both can easily control the handheld leg massager via the handheld controller. It's powered by a 12V/1A adapter.
  • 2 Timing Auto Off Massager: 15-minute and 20-minute timing massage function is added to make your massager time controllable and give you more choices. At the same time, the timing closure is to avoid forgetting to turn off and causing damage to the legs due to overuse. leg massager for circulation with Handheld Controller.
  • One Size Fits Most: Leg air massager with velcro design , Excellent quality fabric, soft comfortable lining, the leg compression massager sleeve can be adjusted easily to change the size and intensity. The leg foot massager ​wraps size is up to 21 inches in circumference. Travel bag is included for easy storage and carrying. Please measure the calf size in advance to determine whether the product can be worn
  • Perfect Gift For The One You Love - The leg massager for pain and circulation is the best gift for your families and friends. The leg compression will be a great massagist for them to enjoy wonderful massage everyday. You no longer need to massage their legs with your hands.Pretty easy to use, If you have any problems while using, please contact us, we will answer your questions within 24 hours and make you satisfied.

I get commissions for purchases made through links on this website. As an Amazon Associate I earn from qualifying purchases.