Mariko Onodera and Jan Meyer perform an experiment with potassium-sensitive microelectrodes in the Institute of Neurobiology at HHU.
Press Release:
During epileptic seizures, a large number of nerve cells in the brain fire excessively and in synchrony. This hyperactivity may lead to uncontrolled shaking of the body and involve periods of loss of consciousness. While about two thirds of patients respond to anti-epileptic medication, the remainder is refractory to medical treatment and shows drug-resistance. These patients are in urgent need for new therapeutic strategies.
Babies born to pregnant women taking the epilepsy drug lamotrigine may not be at an increased risk of birth defects, such as cleft lip, cleft palate or clubfoot, according to a study published in the April 6, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Lamotrigine is an epilepsy drug used on its own or in combination with other medications to control seizures; it is also prescribed to prevent mood swings for those with bipolar disorder. Maintaining effective epilepsy treatment during pregnancy is important because seizures may cause harm to the fetus.
“An initial study of this drug showed an increased risk for cleft lip or cleft palate, but a number of other studies since have not, and a previous study showed an increased risk of clubfoot,” said study author Helen Dolk, PhD, of Ulster University in Northern Ireland, United Kingdom. “This particular study had a much larger population size?more than double the size of the previous study.”
For the study, researchers looked at data on more than 10 million births during a span of 16 years. Of those, there were 226,806 babies with birth defects. Within that group, researchers found 147 babies who were exposed to the drug lamotrigine within the first trimester of pregnancy and who had non-genetic birth defects. Researchers found that babies with cleft lip, cleft palate or clubfoot were not significantly more likely than babies with other birth defects to have been exposed to lamotrigine in the first trimester.
In the general population, one in every 700 babies is born with cleft lip or cleft palate, or 0.14 percent Nearly one in 1,000 babies is born with clubfoot.
“We cannot exclude a small risk, but we estimate the excess risk of cleft lip or cleft palate among babies exposed to the drug to be less than one in every 550 babies. Since excess risks of cleft lip or palate have been reported for a variety of antiepileptic drugs, we recommend that for all mothers with epilepsy, whatever their drug exposure, special attention be given to examining the baby for cleft palate,” said Dolk. “We did not have specific information on lamotrigine dosage so additional study is recommended, especially of high doses.”
This article is based on a press release from the American Academy of Neurology.
❤NOTE: The price is only for the tag, so no watch is included. This stainless steel tag width is 22mm(0.86inch) ,length is 28cm(1.1inch).It fits bands up to 0.86" - 22mm wide. It will be compatible with watches that use bands of 22mm or less.It doesn't fit chain/metal bands because they are too thick. Please make sure to double check your band to confirm it will fit.
❤Style: This is a engraved tag for watch band, it is used for medical or contact information, athletes and also for inspirational sayings. It is an important accessory for people with medical conditions or allergies, Runners, Cyclists, Tri Athletes, Travelers, Kids, older adults and more.
❤Material: the medical id tag is made of high quality stainless steel comfortable to wear, waterproof, lightweight and hypoallergenic. Versatile for work, travel or home wear.
❤Medical Alert Tag: provide your medical information and health status in case of emergency, provide the best rescue method for medical staff at the first time. If you choose [Customized], we recommend you engrave: Your First and Last Name,Medical Condition(s),Treatment Considerations,Food and Drug Allergies,Emergency Contact Number with area code...
❤Package: packed by a nice box, each item will be checked carefully before shippment. Return policy: Fully refund if there is any quality problem or if you are not happy with it.
MEDICAL BRACELET SIZE:Width 0.45 Inches ,Bracelet total length 7.5 Inches,FIT FOR THE WRIST SIZE OF 6.7-7.3 Inches;Material: 316L Stainless Steel&AAA Quality Microfiber Leather,Never Rust,Sturdy and Durable,High Quality.
PEOPLE WITH THE FOLLOWING CONDITIONS SHOULD WEAR A MEDICAL ID JEWELRY:Alzheimer's,Autism/Special Needs Children,Blood Disorders,Blood Thinners,Diabetes,Dementia,Drug Allergies (i.e. Penicillin, morphine, sulfa),Emphysema/Breathing Disorders,Epilepsy/Seizures,Food Allergies,Hearing,vision, or mentally impaired,Heart Disease,Insect Allergies,Kidney Disease,Pulmonary Conditions,Sickle Cell Anemia,Surgery, transplant,cancer patients...
We offer engraving service,please click"Customize Now"select engraving font and fill in your engrave information then "add to cart",we will get your engrave info from your order,if you want change the engrave info after finish the payment,please contact us with your correct engrave info immediately,we will do our best to help you.
WE RECOMMEND YOU ENGRAVE:Medications that you are taking or are allergic to;Allergies: Including, but not limited to Drug, Food, & Insect allergies;ICE: (In case of emergency phone number) This allows a family member or friend to be contacted in case you are in an emergency;Your name, this helps first responders communicate with you in case of an emergency
Come with a Medical ID Cards,Front and back availability for medical and emergency contact information,Carry in Your Wallet. In an emergency,when you might be unable to speak for yourself,a medical ID necklace speaks for you.
COLOR: A pack of 4 --Black,White,Gray and Blue,assorted color for everyday's different outfit
MEASURE: 8x0.47x0.08in .Suit for most adult wrist
Thick High Quality Silicone Bands:good softness, very comfortable to wear. Completely waterproof and hypoallergenic. Perfect medical alert bracelets for outdoor sport
PACKING:Comes with 4 pack Epilepsy bracelet,1 gift box, and a Medical ID Cards (Front and back availability for medical and emergency contact information,Carry in Your Wallet)
Each bracelet is printed with the words "Epilepsy".Corrosion engraving, the font is very clear, durable enough for years of active wear, will not fade or wear off
In Case of Emergency Medical Card has writable ribbon so you can write your personal information and emergency contact, card size is 86x54 mm same as credit card.
SAFETY BREAKAWAY LANYARD: Lanyard with Safety Breakaway clip is 20 mm wide and 45 cm long, Lanyard is made from fabric.
EASY TO WRITE: You can use indelible pen to write on the card, please let the card dry for a little bit after writing on it
ID CARD HOLDER FOR LANYARD: ID card holder Outer size is 80x100mm (3.15x3.94 inches) and Inner size is 60x95 mm( 2.36x 3.74 inches), Horizontal clear double sided id card holder allows both sides of your ID to be read. Id card has waterproof property.
