Nerves release a protein at the injury site that attracts growing nerve fibers and thus keeps them entrapped there. This prevents them from growing in the right direction to bridge the injury. The research team headed by Professor Dietmar Fischer reports in the journal Proceedings of the National Academy of Sciences (PNAS) from 25. May 2021.
There must be another cause
Three main causes for the inability of injured nerves of the central nervous system, or CNS, to regenerate have been known to date: the insufficient activation of a regeneration program in injured nerve cells that stimulates the growth of fibers, so-called axons; the formation of a scar at the site of injury that is difficult for nerve fibers to penetrate; and an inhibitory effect of molecules in the nerve on regrowing axons. “Although experimental approaches have been found in recent decades to address these individual aspects by therapeutic means, even combinatorial approaches have shown only little success,” says Fischer. “So there must be other yet unknown causes for why nerve fibers in the CNS don’t regenerate.”
More than half of people who use medical marijuana products to ease pain also experience clusters of multiple withdrawal symptoms when they’re between uses, a new study finds.
And about 10% of the patients taking part in the study experienced worsening changes to their sleep, mood, mental state, energy and appetite over the next two years as they continued to use cannabis.
Many of them may not recognize that these symptoms come not from their underlying condition, but from their brain and body’s reaction to the absence of substances in the cannabis products they’re smoking, vaping, eating or applying to their skin, says the University of Michigan Addiction Center psychologist who led the study.
When someone experiences more than a few such symptoms, it’s called cannabis withdrawal syndrome – and it can mean a higher risk of developing even more serious issues such as a cannabis use disorder.
University of Colorado Boulder researchers have discovered a brain signature that identifies fibromyalgia sufferers with 93 percent accuracy, a potential breakthrough for future clinical diagnosis and treatment of the highly prevalent condition.
Fibromyalgia is commonly defined as chronic widespread musculoskeletal pain accompanied by symptoms such as fatigue, anxiety and mood disorders. The Centers for Disease Control and Prevention (CDC) estimates that fibromyalgia affects more than five million adults annually in the U.S., with significantly higher occurrence rates in women than in men.