During epileptic seizures, a large number of nerve cells in the brain fire excessively and in synchrony. This hyperactivity may lead to uncontrolled shaking of the body and involve periods of loss of consciousness. While about two thirds of patients respond to anti-epileptic medication, the remainder is refractory to medical treatment and shows drug-resistance. These patients are in urgent need for new therapeutic strategies.
Together with colleagues in Japan, Prof. Dr. Christine Rose and her doctoral student Jan Meyer from the Institute of Neurobiology at HHU have performed a study to address the cellular mechanisms that promote the development of epilepsy. While up to now, most studies and anti-epileptic drugs targeted nerve cells (neurons), this research team focused on a class of glial cells known as astrocytes.
Glial cells account for approximately half of all cells in the brain. There are different types of glial cells, which perform different functions. Astrocytes control the local environment and are responsible for the ion balance in the brain, but also play an important role in signal transmission between neurons.
In their recent paper, the researchers show that epileptic discharges lead to a rise in the pH of astrocytes, that is in their intracellular ‘alkalisation’. The change in pH disrupts the communication within the intercellular astrocyte networks. This reduced communication between astrocytes appears to exacerbate epileptic activity of neurons.
This finding points towards a potential new target for suppressing epileptogenesis at a very early stage, namely by using drugs to suppress changes in astrocytic pH accompanying neuronal activity.
The researchers were able to confirm this option by showing that animals which were given such drugs suffered less severely from epileptic hyperexcitability than untreated animals.
Prof. Rose said: “This observation is very intriguing. But it still needs to be established whether or not it can be transferred to humans. And it will take a very long time before any potential drug can be developed and be really used in the clinics.”
The research was carried out as a collaboration between the HHU and three universities in Japan (Keio University and Tokyo Medical and Dental University in Tokyo, Tohoku University in Sendai) as part of the “Young Glia” programme of the DFG-Priority Programme SPP 1757 “Functional Specialisations of Neuroglia” coordinated by Prof. Rose. This programme promotes collaboration between German and Japanese laboratories. In particular, it encourages and assists young scientists in realising their own bi-national research projects. For example, the HHU doctoral student Jan Meyer travelled to Japan, while Mariko Onodera from Tohoku University spent two periods working at the Institute of Neurobiology in Düsseldorf.
Mariko Onodera, Jan Meyer, Kota Furukawa, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Kenji F. Tanaka, Christine R. Rose, and Ko Matsui, Exacerbation of epilepsy by astrocyte alkalization and gap junction uncoupling, Journal of Neuroscience, 2021
- In Case of Emergency Medical Card has writable ribbon so you can write your personal information and emergency contact, card size is 86x54 mm same as credit card.
- SAFETY BREAKAWAY LANYARD: Lanyard with Safety Breakaway clip is 20 mm wide and 45 cm long, Lanyard is made from fabric.
- EASY TO WRITE: You can use indelible pen to write on the card, please let the card dry for a little bit after writing on it
- ID CARD HOLDER FOR LANYARD: ID card holder Outer size is 80x100mm (3.15x3.94 inches) and Inner size is 60x95 mm( 2.36x 3.74 inches), Horizontal clear double sided id card holder allows both sides of your ID to be read. Id card has waterproof property.
- ✨High-quality material: Made of alloy metal, polished surface, smooth and burr-free, sturdy and durable, don't worry about easy damage, can be used many times.
- ✨Easy to hang: Each brooch is equipped with an easy to open button, which is convenient for you to hang on shirts, T-shirts, sweaters, hats, backpacks, etc. It is a good choice for personalized decoration.
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- QUICK ACCESS + HIGH VISIBILITY – Seat belt location + nighttime reflective trim alerts emergency personnel. Attach/Detach design uses overlapping velcro strips and quick/easy access to patient’s comprehensive medical information.
- HEALTH PROFILE FORM for EPILEPSY – Offering specific areas to disclose seizure type, description, duration, frequency, triggers to seizures, medications and doses, what kind of rescue therapy may be needed, allergies, diet concerns, etc. Fill in the 6.5”H x 9”W tri-fold form by hand OR download and personalize the PDF VERSION- a screen-fillable form you save on your computer to print and update as needed!
- POSITION FOR COMFORT + SAFETY – The MediPal ID’s ability to slide freely along the seatbelt supports a function of the seatbelt retractor: to reel-in an unbuckled seatbelt. Any hinderance of this operation may cause excess belt to dangle below the seat or outside the car door while you are exiting, posing a risk of tripping and falling. Compact size: 4”x2.5” when folded.
- POLYPROPYLENE CONSTRUCTION + PORTABILITY – Backpack material construction helps ensure the MediPal ID lasts for years. Transfers easily to purse, backpack strap or fanny-pack strap, waist belt, and most walker and wheelchair bars. Fits ALL standard and international width seatbelts (46-49mm wide).
- PROVIDES PEACE OF MIND to friends and family members – A great way to reduce the many stresses in our day-to-day lives.
- Sharp, Brooke (Author)
- English (Publication Language)
- 119 Pages - 03/05/2021 (Publication Date) - Independently published (Publisher)
- Laser engraved with EPILEPSY in all caps for easy readability
- Silicone band and stainless steel plate are waterproof and comfortable
- Adjustable size fits men, women and children
- Laser engraving creates a permanent, vibrant mark
- Packed in a gift box, great gift idea
- SIZE: It is 1/4" tall and fits onto smartwatch bands that are 7/8" wide and skinnier.
- MATERIAL: The aluminum material used for our watch charms is known for its corrosion resistance and hypoallergenic properties making it a perfect choice for those with sensitive skin. It is polished to a nice shiny finish.
- PRICELESS: Prioritize safety without compromising on style with this essential accessory.
- INSTALLATION: It slides right onto your watch band so that in case of an emergency, medical personnel will be able to see and know that you have this condition.
- HOW IT'S MADE: The charm is hand stamped and handmade by our small business located in Florida, USA. You will have a unique accessory that is crafted with care. *Please note that as each charm is hand stamped, slight variations in alignment, spacing and depth may occur, further enhancing its unique charm.
- Pollard, L T (Author)
- English (Publication Language)
- 221 Pages - 09/06/2023 (Publication Date) - Independently published (Publisher)
- 【MATERIAL】 The makeup bag is made of cotton and linen, which has strong wear resistance and waterproof function. It is convenient to use at home and travel.
- 【SIZE】23cm*18cm, manual measurement, please allow slight error. The canvas bag can be used to carry cosmetics and toiletries such as lipstick and eyeshadow. It can also be used as a storage bag, making it portable and practical.
- 【DAILY USE】suitable for study, work, business, travel, vacation, camping, fitness, party, shopping use. Light, close-fitting and safe. It can also be a versatile storage bag for storing small items at home, work or school.
- 【GIVE FOR ANY OCCASION】Give it to your grandma, friends, sister, girlfriend, mother, child, teacher as a surprise. It is the perfect gift for important people's birthdays, Valentines, Thanksgivings, and graduations.
- 【GUARANTEE】We are committed to providing customers with high quality products and thoughtful service. If you receive the goods or have any problems using our products, please let us know by email.
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