Epilepsy drug may not increase risk of birth defects

Babies born to pregnant women taking the epilepsy drug lamotrigine may not be at an increased risk of birth defects, such as cleft lip, cleft palate or clubfoot, according to a study published in the April 6, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Lamotrigine is an epilepsy drug used on its own or in combination with other medications to control seizures; it is also prescribed to prevent mood swings for those with bipolar disorder. Maintaining effective epilepsy treatment during pregnancy is important because seizures may cause harm to the fetus.

“An initial study of this drug showed an increased risk for cleft lip or cleft palate, but a number of other studies since have not, and a previous study showed an increased risk of clubfoot,” said study author Helen Dolk, PhD, of Ulster University in Northern Ireland, United Kingdom. “This particular study had a much larger population size?more than double the size of the previous study.”

For the study, researchers looked at data on more than 10 million births during a span of 16 years. Of those, there were 226,806 babies with birth defects. Within that group, researchers found 147 babies who were exposed to the drug lamotrigine within the first trimester of pregnancy and who had non-genetic birth defects. Researchers found that babies with cleft lip, cleft palate or clubfoot were not significantly more likely than babies with other birth defects to have been exposed to lamotrigine in the first trimester.

In the general population, one in every 700 babies is born with cleft lip or cleft palate, or 0.14 percent Nearly one in 1,000 babies is born with clubfoot.

“We cannot exclude a small risk, but we estimate the excess risk of cleft lip or cleft palate among babies exposed to the drug to be less than one in every 550 babies. Since excess risks of cleft lip or palate have been reported for a variety of antiepileptic drugs, we recommend that for all mothers with epilepsy, whatever their drug exposure, special attention be given to examining the baby for cleft palate,” said Dolk. “We did not have specific information on lamotrigine dosage so additional study is recommended, especially of high doses.”

This article is based on a press release from the American Academy of Neurology.


Bestseller No. 1
Epilepsy Awareness Purple Epileptic Brain Epilepsia T-Shirt
  • This cool Epilepsy graphic shows a cute stuffed toy and a quote says My Brain Waves Are So Powerful Doctors Study Them. An awesome treat for Epilepsy patients, survivors, and warriors who supports raising awareness about central nervous system disorder.
  • This design is a perfect idea for men and women that are looking for excellent wear in the celebration of National Epilepsy Awareness Month. Let's educate people experiencing this lateral disorder to know its symptoms, complication, and treatment.
  • Lightweight, Classic fit, Double-needle sleeve and bottom hem
Bestseller No. 2
Medical Card Awareness with Writable Panel and Patterned Lanyard, Emergency Contact PVC Card (Epilepsy)
  • In Case of Emergency Medical Card has writable ribbon so you can write your personal information and emergency contact, card size is 86x54 mm same as credit card.
  • SAFETY BREAKAWAY LANYARD: Lanyard with Safety Breakaway clip is 20 mm wide and 45 cm long, Lanyard is made from fabric.
  • EASY TO WRITE: You can use indelible pen to write on the card, please let the card dry for a little bit after writing on it
  • ID CARD HOLDER FOR LANYARD: ID card holder Outer size is 80x100mm (3.15x3.94 inches) and Inner size is 60x95 mm( 2.36x 3.74 inches), Horizontal clear double sided id card holder allows both sides of your ID to be read. Id card has waterproof property.
Bestseller No. 3
Epilepsy: Epilepsy awareness journal Book, A Daily Mood, Pain, Symptoms, Food.. Tracker book For Epilepsy survivors, Health and Wellbeing diary
  • Design, Ansart (Author)
  • English (Publication Language)
  • 120 Pages - 03/06/2020 (Publication Date) - Independently published (Publisher)
Bestseller No. 4
Her Fight Is My Fight | Epilepsy Survivor Purple Ribbon T-Shirt
  • Cute epilepsy awareness idea for moms of epilepsy warriors featuring the purple ribbon. Perfect choice for epilepsy awareness month.
  • Perfect to raise awareness for epilepsy and show support for epilepsy fighters.
  • Lightweight, Classic fit, Double-needle sleeve and bottom hem
Bestseller No. 5
MediPal’s Epilepsy Alert Medical ID Seatbelt Tag- List Seizure Type, Description, Triggers, Best Response, Meds, Contacts, Allergies, Diet + Customizable PDF Version
  • QUICK ACCESS + HIGH VISIBILITY – Seat belt location + nighttime reflective trim alerts emergency personnel. Attach/Detach design uses overlapping velcro strips and quick/easy access to patient’s comprehensive medical information.
  • HEALTH PROFILE FORM for EPILEPSY – Offering specific areas to disclose seizure type, description, duration, frequency, triggers to seizures, medications and doses, what kind of rescue therapy may be needed, allergies, diet concerns, etc. Fill in the 6.5”H x 9”W tri-fold form by hand OR download and personalize the PDF VERSION- a screen-fillable form you save on your computer to print and update as needed!
  • POSITION FOR COMFORT + SAFETY – The MediPal ID’s ability to slide freely along the seatbelt supports a function of the seatbelt retractor: to reel-in an unbuckled seatbelt. Any hinderance of this operation may cause excess belt to dangle below the seat or outside the car door while you are exiting, posing a risk of tripping and falling. Compact size: 4”x2.5” when folded.
  • POLYPROPYLENE CONSTRUCTION + PORTABILITY – Backpack material construction helps ensure the MediPal ID lasts for years. Transfers easily to purse, backpack strap or fanny-pack strap, waist belt, and most walker and wheelchair bars. Fits ALL standard and international width seatbelts (46-49mm wide).
  • PROVIDES PEACE OF MIND to friends and family members – A great way to reduce the many stresses in our day-to-day lives.
Bestseller No. 6
Epilepsy: The Ultimate Teen Guide (Volume 2) (It Happened to Me, 2)
  • Used Book in Good Condition
  • Gay, Kathlyn (Author)
  • English (Publication Language)
  • 112 Pages - 11/09/2007 (Publication Date) - Scarecrow Press (Publisher)
Bestseller No. 7
VNOX Blue Braided Leather Medical Symbol Caduceus with Stainless Steel Cuff Wristband Bracelet,7.5 Inches-EPILEPSY
  • MEDICAL BRACELET SIZE:Width 0.45 Inches ,Bracelet total length 7.5 Inches,FIT FOR THE WRIST SIZE OF 6.5-7.4 Inches;Material: 316L Stainless Steel&AAA Quality Microfiber Leather,Never Rust,Sturdy and Durable,High Quality.
  • PEOPLE WITH THE FOLLOWING CONDITIONS SHOULD WEAR A MEDICAL ID JEWELRY:Alzheimer's,Autism/Special Needs Children,Blood Disorders,Blood Thinners,Diabetes,Dementia,Drug Allergies (i.e. Penicillin, morphine, sulfa),Emphysema/Breathing Disorders,Epilepsy/Seizures,Food Allergies,Hearing,vision, or mentally impaired,Heart Disease,Insect Allergies,Kidney Disease,Pulmonary Conditions,Sickle Cell Anemia,Surgery, transplant,cancer patients...
  • We offer engraving service,please click"Customize Now"select engraving font and fill in your engrave information then "add to cart",we will get your engrave info from your order,if you want change the engrave info after finish the payment,please contact us with your correct engrave info immediately,we will do our best to help you.
  • WE RECOMMEND YOU ENGRAVE:Medications that you are taking or are allergic to;Allergies: Including, but not limited to Drug, Food, & Insect allergies;ICE: (In case of emergency phone number) This allows a family member or friend to be contacted in case you are in an emergency;Your name, this helps first responders communicate with you in case of an emergency
  • Come with a Medical ID Cards,Front and back availability for medical and emergency contact information,Carry in Your Wallet. In an emergency,when you might be unable to speak for yourself,a medical ID necklace speaks for you.
Bestseller No. 9
Epilepsy Awareness Stickers 60pcs Brain Disease Decals Aesthetic Waterproof Vinyl Pack Stickers for Water Bottle Laptop Cup Car Kids Adults Teens Girls Phone Skateboard DIY Party Supplie
  • 【Pack】water bottle stickers, there are 60 different stickers, no random shipment, no duplicate shipment.Sizes from 2 to 4 inches. All decals are 100% brand new to satisfy fans' love for this style.
  • 【Excellent Quality】Water bottle stickers are made of high-quality vinyl material, which is safe, non-toxic, and waterproof.Each beautiful vinyl sticker features a durable laminate that protects it from harmful UV rays and is easy to apply. The stickers can be reapplied and removed without leaving a sticky residue.
  • 【Amazing Gift】Our assortment of graffiti decals is your right choice when choosing a gift for your kids, teens, family, and friends.Perfect for birthday presents, party gifts, or housewarming gifts.
  • 【Wide Application】Perfect to embellish laptops, trackpads, keyboards, backpacks, skateboards, luggage, water bottles,scrapbooks, mirrors, notebooks, journals, cars, bumpers, bikes, bedroom, travel case, motorcycle, snowboard.Feel free to customize your belongings, and make your personality shine.
  • 【Special Promise】We guarantee that you are completely satisfied with the product or get a refund. We work with Amazon FBA to provide you with the highest quality Amazon Prime delivery and worry-free returns.
Bestseller No. 10
Epilepsy: Complementary And Alternative Treatments
  • Baxendale, Sallie (Author)
  • English (Publication Language)
  • 224 Pages - 01/19/2012 (Publication Date) - Sheldon Press (Publisher)

I get commissions for purchases made through links on this website. As an Amazon Associate I earn from qualifying purchases.