DALLAS – Dec. 21, 2020 – A UT Southwestern research team has catalogued gene activity in the skeletal muscle of mice, comparing healthy animals to those carrying a genetic mutation that causes Duchenne muscular dystrophy (DMD) in humans. The findings, published online recently in PNAS, could lead to new treatments for this devastating degenerative disease and insights into factors that affect muscle development.
Understanding the activity of genes can shed light on pathologies that affect different tissues in the body. However, says Rhonda Bassel-Duby, Ph.D., a professor of molecular biology at UTSW, studying skeletal muscle has been a challenge because of a key difference from other tissue types; rather than containing a single nucleus that controls the activity of the genes, a skeletal muscle fiber can contain hundreds of nuclei. And it was unknown which genes were activated in all these nuclei, making it unclear how gene expression differs between healthy skeletal muscle tissue and tissue affected by DMD.
Babies born to pregnant women taking the epilepsy drug lamotrigine may not be at an increased risk of birth defects, such as cleft lip, cleft palate or clubfoot, according to a study published in the April 6, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Lamotrigine is an epilepsy drug used on its own or in combination with other medications to control seizures; it is also prescribed to prevent mood swings for those with bipolar disorder. Maintaining effective epilepsy treatment during pregnancy is important because seizures may cause harm to the fetus.
“An initial study of this drug showed an increased risk for cleft lip or cleft palate, but a number of other studies since have not, and a previous study showed an increased risk of clubfoot,” said study author Helen Dolk, PhD, of Ulster University in Northern Ireland, United Kingdom. “This particular study had a much larger population size?more than double the size of the previous study.”
For the study, researchers looked at data on more than 10 million births during a span of 16 years. Of those, there were 226,806 babies with birth defects. Within that group, researchers found 147 babies who were exposed to the drug lamotrigine within the first trimester of pregnancy and who had non-genetic birth defects. Researchers found that babies with cleft lip, cleft palate or clubfoot were not significantly more likely than babies with other birth defects to have been exposed to lamotrigine in the first trimester.
In the general population, one in every 700 babies is born with cleft lip or cleft palate, or 0.14 percent Nearly one in 1,000 babies is born with clubfoot.
“We cannot exclude a small risk, but we estimate the excess risk of cleft lip or cleft palate among babies exposed to the drug to be less than one in every 550 babies. Since excess risks of cleft lip or palate have been reported for a variety of antiepileptic drugs, we recommend that for all mothers with epilepsy, whatever their drug exposure, special attention be given to examining the baby for cleft palate,” said Dolk. “We did not have specific information on lamotrigine dosage so additional study is recommended, especially of high doses.”
This article is based on a press release from the American Academy of Neurology.
In Case of Emergency Medical Card has writable ribbon so you can write your personal information and emergency contact, card size is 86x54 mm same as credit card.
SAFETY BREAKAWAY LANYARD: Lanyard with Safety Breakaway clip is 20 mm wide and 45 cm long, Lanyard is made from fabric.
EASY TO WRITE: You can use indelible pen to write on the card, please let the card dry for a little bit after writing on it
ID CARD HOLDER FOR LANYARD: ID card holder Outer size is 80x100mm (3.15x3.94 inches) and Inner size is 60x95 mm( 2.36x 3.74 inches), Horizontal clear double sided id card holder allows both sides of your ID to be read. Id card has waterproof property.
MEDICAL BRACELET SIZE:Width 0.45 Inches ,Bracelet total length 7.5 Inches,FIT FOR THE WRIST SIZE OF 6.5-7.4 Inches;Material: 316L Stainless Steel&AAA Quality Microfiber Leather,Never Rust,Sturdy and Durable,High Quality.
PEOPLE WITH THE FOLLOWING CONDITIONS SHOULD WEAR A MEDICAL ID JEWELRY:Alzheimer's,Autism/Special Needs Children,Blood Disorders,Blood Thinners,Diabetes,Dementia,Drug Allergies (i.e. Penicillin, morphine, sulfa),Emphysema/Breathing Disorders,Epilepsy/Seizures,Food Allergies,Hearing,vision, or mentally impaired,Heart Disease,Insect Allergies,Kidney Disease,Pulmonary Conditions,Sickle Cell Anemia,Surgery, transplant,cancer patients...
We offer engraving service,please click"Customize Now"select engraving font and fill in your engrave information then "add to cart",we will get your engrave info from your order,if you want change the engrave info after finish the payment,please contact us with your correct engrave info immediately,we will do our best to help you.
WE RECOMMEND YOU ENGRAVE:Medications that you are taking or are allergic to;Allergies: Including, but not limited to Drug, Food, & Insect allergies;ICE: (In case of emergency phone number) This allows a family member or friend to be contacted in case you are in an emergency;Your name, this helps first responders communicate with you in case of an emergency
Come with a Medical ID Cards,Front and back availability for medical and emergency contact information,Carry in Your Wallet. In an emergency,when you might be unable to speak for yourself,a medical ID necklace speaks for you.